Home > Research > Cofoni > Projects

Projects

COFONI

Our projects in key area 1 – Epidemiological modelling

There are no projects in key area 1

Our projects in key area 2 – Antiviral strategies

Activity of human broadly neutralising antibodies in a SARS-CoV-2 primate model

Sites: MHH, DPZ

Project leader: Prof. Dr. Thomas Schulz

CRISPR/Cas13-mediated antiviral therapy against SARS-CoV-2 and its variants: a novel technology to target viral genome

Sites: UMG, DPZ, TiHo

Project leader: Prof. Dr. med. Elisabeth Zeisberg

In vivo testing of human monoclonal antibodies in a hamster model

Sites: TiHo, TWINCORE

Project leader: Prof. Dr. Albert Osterhaus

LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2

Sites: HZI, MHH, CiiM, DPZ

Project leader: Prof. Dr. Jochen Hühn

Nsp15 inhibitors for preventing future viral pandemics (Nsp15 VIPA)

Sites: LUH, HZI, TWINCORE, TiHo

Project leader: Prof. Dr. Oliver Plettenburg

Preclinical development of a bispecific human-derived SARS-CoV-2 neutralizing monoclonal antibody (PREHUMAB)

Sites: TWINCORE, MHH, DPZ

Project leader: Prof. Dr. Ulrich Kalinke

SARS-CoV-2 antigenic cartography for future COVID-19 vaccine composition

Sites: TiHo, DPZ

Project leaders: Prof. Dr. Albert Osterhaus, Dr. Imke Steffen

Detection dogs as first line screening method for SARS-CoV-2 infections

Sites: TiHo, MHH

Project leader: Prof. Dr. Holger A. Volk

Synergistic inhibition of SARS-CoV-2 replication by pyrimidine analogues and inhibitors of pyrimidine synthesis

Sites: UMG, TiHo

Project leader: Prof. Dr. med. Matthias Dobbelstein

Validation of FDA-approved small molecule kinase inhibitor (SMKI) candidates as SARS-CoV-2 therapeutics in a human ex vivo system

Sites: TiHo, MHH

Project leader: Dr. Husni Elbahesh

Prediction of Escape Mutants (PREMUS)

Sites: TUBS, HZI, DPZ

Project leader: Prof. Dr. Stefan Dübel

Our projects in key area 3 – Digital infectious medicine

Revealing genetic regulation of immune response to SARS-CoV2 infection using single-cell omics approaches

Sites: CiiM, MHH

Project leader: Prof. Dr. Yang Li

LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2

Sites: HZI, MHH, CiiM, DPZ

Project leader: Prof. Dr. Jochen Hühn

Technology platform animal models meets biobanking and databases

Sites: TiHo, UMG, MHH, DPZ

Project leader: Prof. Dr. Maren von Köckritz-Blickwede

Our projects in key area 4 – Pathophysiology

Air-liquid interface cultures of human primary distal respiratory epithelial for in vitro modelling of SARS-CoV-2 infections

Sites: MHH, TiHo

Project leader: Dr. Ruth Olmer

Antibody dynamics in Long COVID patients of the IRMI-19 cohort and oncological patients of the ONCOVID-VAC cohort

Sites: MHH, UMG, TWINCORE

Project leader: Prof. Dr. Christine S. Falk

Revealing genetic regulation of immune response to SARS-CoV2 infection using single-cell omics approaches

Sites: CiiM, MHH

Project leader: Prof. Dr. Yang Li

Impact of SARS-CoV-2 infection on the molecular initiation of neurodegeneration

Sites: MHH, TWINCORE, UMG

Project leader: PD Dr. med. Franziska Hopfner

COVID-19 infection and vaccination in patients with inflammatory bowel disease (IBD)

Sites: MHH, CiiM

Project leader: Dr. med. Henrike Lenzen

Role of the lung microbiome during SARS-CoV-2 infections

Sites: UMG, TiHo

Project leaders: Prof. Dr. Dr. Francesca Odoardi, Prof. Dr. Alexander Flügel

Role of TMPRSS2 proteolysis in SARS-CoV-2 spread in cells of the respiratory tract and in vivo

Sites: HZI, DPZ, MHH, Fraunhofer ITEM

Project leader: Prof. Dr. Luka Čičin-Šain

Immunothrombosis in cerebrovascular complications related to SARS-CoV-2 infection and vaccine-induced immune thrombotic thrombocytopenia (ISI-VITT)

Sites: TiHo, MHH

Project leader: Dr. Nicole de Buhr

LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2

Sites: HZI, MHH, CiiM, DPZ

Project leader: Prof. Dr. Jochen Hühn

LOCO-PIN: Long COVID pneumological, immunological and neurological investigation of novel treatment options

Sites: MHH, UMG, TWINCORE

Project leader: Prof. Dr. med. Tobias Welte

Mechanisms of short- and long-term effects of SARS-CoV-2 infection on the integrity of respiratory tract epithelia

Sites: TiHo, HZI

Project leader: Prof. Dr. Wolfgang Baumgärtner

Protective immunity against SARS-CoV-2 in immunosuppressed COVID-19 convalescents after liver transplantation

Sites: MHH, CiiM

Project leader: Dr. med. Richard Taubert

Investigation of circular RNAs as mediators of SARS-CoV-2 infection in the cardiovascular system

Sites: MHH, TWINCORE

Project leader: Prof. Dr. Thomas Thum

Validation of FDA-approved small molecule kinase inhibitor (SMKI) candidates as SARS-CoV-2 therapeutics in a human ex vivo system

Sites: TiHo, MHH

Project leader: Dr. Husni Elbahesh

Our projects in key area 5 – Interdisciplinary research on the long-term effects of the SARS-CoV-2 pandemic

Research field 1 - Basic and translational research on post COVID

Post-COVID Omics - Integrative analysis of multi-omics data and immune function during long/post COVID and target search for therapeutic use

Sites: CiiM, MHH

Project leader: Prof. Dr. Yang Li

Type I interferon signaling and mitochondrial dysfunction in the heart in acute and long/post COVID disease

Sites: MHH, TWINCORE, TiHo

Project leader: Dr. Georgios Amanakis

Extracorporal apheresis study in post COVID patients (EXTINCT post COVID)

Sites: MHH, TiHo

Project leader: Dr. Vega Gödecke

Detecting and Deciphering post COVID with Dogs, Metabolomics and Machine Learning (COVID Dogolomics)

Sites: TiHo, MHH, TU BS

Project leader: Prof. Dr. Holger A. Volk

Role of sex hormone metabolism in long COVID

Sites: TiHo/LIV, TiHo, MHH

Project leader: Prof. Dr. Gülşah Gabriel

Non-Invasive diagnostics of post-COVID patients with persistent dyspnea supported by KI - NICK

Sites: MHH, LUH, RWTH Aachen

Project leader: Dr. Isabell Pink

Monitoring and modelling post-COVID neurocognitive symptom trajectories, determinants and long-term impact on life and work

Sites: UOL, MHH

Project leader: Prof. Dr. Mandy Roheger

Research field 2 - Health services research with regard to the long-term impacts of the pandemic

Health care of patients with post-COVID: Analyses of health insurance claims data and of the perspectives of patients, relatives and general practitioners

Sites: MHH, AOK, UMG, LUH

Project leader: Prof. Dr. Nils Schneider

Randomized trial of telemedicine-assisted exercise and psychotherapy in patients with post COVID-19 syndrome

Sites: MHH, Volkswagen Gesundheitswesen, Audi BKK, HZI

Project leader: Prof. Dr. Uwe Tegtbur

Bereaved significant others of patients at the end of live during the pandemic - experiences with care and of mental stress, and with consideration of migration background

Sites: UMG, MHH

Project leader: Dr. Christian Banse

Research field 3 - Interdisciplinary research on pandemic long-term impacts on living and working conditions

COFONI Working World Monitor - Long-term consequences of the pandemic, long/post COVID and occupational inequalities

Sites: UOS, TU BS, University of Göttingen, HsH, MHH

Project leader: Prof. Dr. Hajo Holst

Workplace health policies in response to the pandemic – perspectives on cooperation between companies and external actors

Sites: SOFI, DRV, AOK, MS

Project leader: Dr. Martin Kuhlmann

Monitoring and modelling post-COVID neurocognitive symptom trajectories, determinants and long-term impact on life and work

Sites: UOL, MHH

Project leader: Prof. Dr. Mandy Roheger

Research field 4 - Mental health of children and adolescents and their families

CoMpsyKids: Impact of Covid-19 related interventions on the mental health of children and adolescents in Lower Saxony

Sites: UOL, UMG

Project leader: Prof. Dr. Falk Hoffmann

JuPaCo - Long-term psychosocial consequences for young people from the SARS-CoV-2 pandemic

Sites: UHI, Leuphana

Project leader: Prof. Dr. Wolfgang Schröer

Projects

Our projects in key area 1 – Epidemiological modelling

Our projects in key area 2 – Antiviral strategies

Activity of human broadly neutralising antibodies in a SARS-CoV-2 primate model

CRISPR/Cas13-mediated antiviral therapy against SARS-CoV-2 and its variants: a novel technology to target viral genome

In vivo testing of human monoclonal antibodies in a hamster model

LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2

Nsp15 inhibitors for preventing future viral pandemics (Nsp15 VIPA)

Preclinical development of a bispecific human-derived SARS-CoV-2 neutralizing monoclonal antibody (PREHUMAB)

SARS-CoV-2 antigenic cartography for future COVID-19 vaccine composition

Detection dogs as first line screening method for SARS-CoV-2 infections

Synergistic inhibition of SARS-CoV-2 replication by pyrimidine analogues and inhibitors of pyrimidine synthesis

Validation of FDA-approved small molecule kinase inhibitor (SMKI) candidates as SARS-CoV-2 therapeutics in a human ex vivo system

Prediction of Escape Mutants (PREMUS)

Our projects in key area 3 – Digital infectious medicine

Revealing genetic regulation of immune response to SARS-CoV2 infection using single-cell omics approaches

LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2

Technology platform animal models meets biobanking and databases

Our projects in key area 4 – Pathophysiology

Air-liquid interface cultures of human primary distal respiratory epithelial for in vitro modelling of SARS-CoV-2 infections

Antibody dynamics in Long COVID patients of the IRMI-19 cohort and oncological patients of the ONCOVID-VAC cohort

Revealing genetic regulation of immune response to SARS-CoV2 infection using single-cell omics approaches

Impact of SARS-CoV-2 infection on the molecular initiation of neurodegeneration

COVID-19 infection and vaccination in patients with inflammatory bowel disease (IBD)

Role of the lung microbiome during SARS-CoV-2 infections

Role of TMPRSS2 proteolysis in SARS-CoV-2 spread in cells of the respiratory tract and in vivo

Immunothrombosis in cerebrovascular complications related to SARS-CoV-2 infection and vaccine-induced immune thrombotic thrombocytopenia (ISI-VITT)

LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2

LOCO-PIN: Long COVID pneumological, immunological and neurological investigation of novel treatment options

Mechanisms of short- and long-term effects of SARS-CoV-2 infection on the integrity of respiratory tract epithelia

Protective immunity against SARS-CoV-2 in immunosuppressed COVID-19 convalescents after liver transplantation

Investigation of circular RNAs as mediators of SARS-CoV-2 infection in the cardiovascular system

Validation of FDA-approved small molecule kinase inhibitor (SMKI) candidates as SARS-CoV-2 therapeutics in a human ex vivo system

Our projects in key area 5 – Interdisciplinary research on the long-term effects of the SARS-CoV-2 pandemic

Post-COVID Omics - Integrative analysis of multi-omics data and immune function during long/post COVID and target search for therapeutic use

Type I interferon signaling and mitochondrial dysfunction in the heart in acute and long/post COVID disease

Extracorporal apheresis study in post COVID patients (EXTINCT post COVID)

Detecting and Deciphering post COVID with Dogs, Metabolomics and Machine Learning (COVID Dogolomics)

Role of sex hormone metabolism in long COVID

Non-Invasive diagnostics of post-COVID patients with persistent dyspnea supported by KI - NICK

Monitoring and modelling post-COVID neurocognitive symptom trajectories, determinants and long-term impact on life and work

Health care of patients with post-COVID: Analyses of health insurance claims data and of the perspectives of patients, relatives and general practitioners

Randomized trial of telemedicine-assisted exercise and psychotherapy in patients with post COVID-19 syndrome

Bereaved significant others of patients at the end of live during the pandemic - experiences with care and of mental stress, and with consideration of migration background

COFONI Working World Monitor - Long-term consequences of the pandemic, long/post COVID and occupational inequalities

Workplace health policies in response to the pandemic – perspectives on cooperation between companies and external actors

Monitoring and modelling post-COVID neurocognitive symptom trajectories, determinants and long-term impact on life and work

CoMpsyKids: Impact of Covid-19 related interventions on the mental health of children and adolescents in Lower Saxony

JuPaCo - Long-term psychosocial consequences for young people from the SARS-CoV-2 pandemic

Follow us